In the California desert, a tire comes to life and embarks on a killing spree as an audience watches the events unfold through binoculars. The tire kills by vibrating intensely and psycho-kinetically causes people's heads to explode. The audience is poisoned by individuals that seem to be orchestrating the film's events. A sheriff investigating the murders is inside and outside the diegesis, sometimes participating in the narrative action and sometimes commenting on it.
In the end, the tire is destroyed, but then reincarnated as a tricycle. The tricycle recruits several tires and rolls to Hollywood, where the film concludes. - WIkipedia