Rowf (a Labrador-mix) and Snitter (a smooth fox terrier) are two of many dogs used for experimental purposes at an animal research facility in the Lake District of north-western England. Eager to escape the tortures of life inside the facility, an escape is managed. Initially relieved and eager to experience their new freedom the dogs are soon faced, not only with the realities of life in the wild, but with another more terrifying realization — they are being hunted by their former captors.
Differences between the film plot and the book plot are numerous and have substantial bearing on the outcome of the film. The most significant is that the survival of the dogs at the end of the film seems very unlikely, whereas in the book they are rescued and returned to Snitter's original owner, who in the book has survived (in the movie he has not, making Snitter a true orphan). Other differences are linked to the alteration of certain characters and to an overall compression of the time sequences and series of events outlined in the book
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